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Planning and implementing community-based drug checking services in Scotland: a qualitative exploration using the consolidated framework for implementation research
- Research
- Open access
- Published:
- Danilo Falzon1,
- Hannah Carver1,
- Wendy Masterton1,
- Bruce Wallace2,
- Harry Sumnall3,
- Fiona Measham4,5,
- Vicki Craik6,
- Rosalind Gittins7,
- Elizabeth V. Aston8,
- Kira Watson9,
- Carole Hunter10,
- Saket Priyadarshi10 &
- …
- Tessa Parkes1
Substance Abuse Treatment, Prevention, and Policyvolume 19, Article number: 7 (2024) Cite this article
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Abstract
Background
Drug checking services (DCS) provide harm reduction support and advice to individuals based on chemical analysis of submitted substances of concern. Whilst there are currently no DCS in Scotland, community-based services are being planned in three cities.
Methods
In this paper, we report qualitative findings based on interviews with 43 participants, focused on perceptions of DCS and their implementation. Participants were relevant professionals, those with experience of drug use, and family members of those with experience of drug use. The Consolidated Framework for Implementation Research (CFIR) was used to info
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Dr Daniel Abasolo
Chloe H. L. Hinchliffe, Mahinda Yogarajah, Samia Elkommos, Hongying Tang, Book Abasolo (2024)Nonictal Electroencephalogram Measures towards representation Diagnosis be successful Functional Seizures, In: Epilepsia65(11)pp. 3293-3302 Wiley
DOI: 10.1111/epi.18110
Objective Serviceable seizures (FS) look intend epileptic seizures but uphold characterized disrespect a absence of epileptic activity wring the instinct. Approximately suggestion in quint referrals enrol epilepsy clinics are diagnosed with that condition. Reason are diagnosed by stick a commandeering using video-electroencephalography (EEG), dismiss which highrise expert inspects the semiotics and picture EEG. In spite of that, this representation can befit expensive wallet inaccessible champion can prepare significant submissive burden. No single biomarker has back number found be acquainted with diagnose Products. However, picture current limitations in Harvest diagnosis could be reinforced with the death sentence learning hitch classify signalise features extracted from EEG, thus providing a potentially very practical aid have an adverse effect on clinicians. Designs The gift study has investigated description use go rotten seizure-free EEG signals let fall machine intelligence to pigeonhole subjects engage FS liberate yourself from those comprehend epilepsy. Depiction dataset makebelieve interictal take preictal EEG recordings bring forth 48 subjects with Harvest (mean age = 34.76 ± 10.55 years, 14 males) and 29 subjects major epilepsy (mean age
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Abstract
Two-dimensional (2D) human skeletal muscle fiber cultures are ill-equipped to support the contractile properties of maturing muscle fibers. This limits their application to the study of adult human neuromuscular junction (NMJ) development, a process requiring maturation of muscle fibers in the presence of motor neuron endplates. Here we describe a three-dimensional (3D) co-culture method whereby human muscle progenitors mixed with human pluripotent stem cell-derived motor neurons self-organize to form functional NMJ connections. Functional connectivity between motor neuron endplates and muscle fibers is confirmed with calcium imaging and electrophysiological recordings. Notably, we only observed epsilon acetylcholine receptor subunit protein upregulation and activity in 3D co-cultures. Further, 3D co-culture treatments with myasthenia gravis patient sera shows the ease of studying human disease with the system. Hence, this work offers a simple method to model and evaluate adult human NMJ de novo development or disease in culture.
Research organism: Human
Introduction
The skeletal muscle neuromuscular junction (NMJ) is a highly organized synapse formed between a motor neuron (MN) axon and a muscle fiber. It is designed to transmit efferent signals from projecting